Perturbing the Ubiquitin Pathway Reveals How Mitosis Is Hijacked to Denucleate and Regulate Cell Proliferation and Differentiation In Vivo
Title | Perturbing the Ubiquitin Pathway Reveals How Mitosis Is Hijacked to Denucleate and Regulate Cell Proliferation and Differentiation In Vivo |
Publication Type | Journal Articles |
Year of Publication | 2010 |
Authors | Caceres A, Shang F, Wawrousek E, Liu Q, Avidan O, Cvekl A, Yang Y, Haririnia A, Storaska A, Fushman D, Kuszak J, Dudek E, Smith D, Taylor A |
Journal | PLoS ONEPLoS ONE |
Volume | 5 |
Issue | 10 |
Pagination | e13331 - e13331 |
Date Published | 2010/10/20/ |
Abstract | BackgroundThe eye lens presents a unique opportunity to explore roles for specific molecules in cell proliferation, differentiation and development because cells remain in place throughout life and, like red blood cells and keratinocytes, they go through the most extreme differentiation, including removal of nuclei and cessation of protein synthesis. Ubiquitination controls many critical cellular processes, most of which require specific lysines on ubiquitin (Ub). Of the 7 lysines (K) least is known about effects of modification of K6. |
URL | http://dx.doi.org/10.1371/journal.pone.0013331 |
DOI | 10.1371/journal.pone.0013331 |